SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                            -----------------------


                                  SCHEDULE 13D
                                 (Rule 13d-101)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                 RULE 13d-2(a)

                               (Amendment No. 6)


                   LABORATORY CORPORATION OF AMERICA HOLDINGS
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                         COMMON STOCK, $0.10 PAR VALUE
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                  5054OR 10 2
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                                Peter R. Douglas
                             Davis Polk & Wardwell
                              450 Lexington Avenue
                               New York, NY 10017
                            Tel. No.: (212) 450-4000
- --------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


                               February 21, 2002
- --------------------------------------------------------------------------------
            (Date of Event which Requires Filing of This Statement)

     If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1 (b)(3) or (4), check the following box [ ].

          Note. This document is being electronically filed with the Commission
     using the EDGAR system. See Rule 13d-1 (a) for other parties to whom
     copies are to be sent.

     *The remainder of this cover page should be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

     The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).





Schedule 13D - -------------------------------------------------------------------------------- - --------------------- ----------------- CUSIP No. 5054OR 10 2 13D Page 2 of 8 Pages - --------------------- ----------------- 1 NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS Roche Holdings, Inc. 51-0304944 - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS WC - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e). [ ] - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 7 SOLE VOTING POWER 10,705,074 shares of Common Stock NUMBER OF SHARES ---------------------------------------------------------------- BENEFICIALLY 8 SHARED VOTING POWER N/A OWED BY EACH ---------------------------------------------------------------- REPORTING 9 SOLE DISPOSITIVE POWER 10,705,074 shares of Common Stock PERSON WITH ---------------------------------------------------------------- 10 SHARED DISPOSITIVE POWER N/A - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 10,705,074 shares of Common Stock - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES [ ] - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) 15.1% of Common Stock - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON CO, HC - --------------------------------------------------------------------------------

The following information amends and supplements the Schedule 13D dated April 28, 1995, as previously amended (as so amended, the "Schedule 13D"). Item 4. Purpose of Transaction Item 4 of the Schedule 13D is hereby amended by adding the following: Holdings plans to sell 7.0 million shares of the Company's Common Stock in an underwritten public offering. Holdings also plans to grant to the underwriters a 30-day option to purchase an additional 700,000 shares to cover over- allotments, if any. Holdings currently owns 10,705,074 shares or 15.13% of the Company's Common Stock. Following the offering, Holdings' ownership of the Company's Common Stock will be approximately 5.24% (4.25% if the underwriters' over-allotment option is exercised in full). Except as described below, all of Holdings' rights with respect to the Stockholder Agreement will terminate as a result of the proposed offering. Holdings currently has the right to designate one director for nomination to the Board of Directors of the Company. Following the proposed offering, Holdings will no longer have the right to designate a director. Currently, the Board of Directors of the Company is comprised of seven members. Holdings will continue to have demand registration rights and have the benefits of various covenants of the Company with respect to transfers made by the selling stockholder pursuant to Rule 144A under the Securities Act of 1933. The Company has filed a registration statement with the Securities and Exchange Commission relating to the proposed offer and sale by Holdings of the Company's Common Stock, but the registration statement has not yet become effective. Such securities may not be sold nor may offers to buy such securities be accepted prior to the time such registration statement becomes effective. Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer Item 6 of the Schedule 13D is hereby amended by adding the following: Holdings has entered into a number of call option contracts with respect to the remaining 3,005,074 shares of the Company's Common Stock it currently owns which are not covered by the registration statement described in Item 4 above. Each of these call option contracts is similar in form and permits the counterparty to purchase from Holdings a specified number of shares of the Company's Common Stock, at a price ranging from $75 to $80 per share, upon the expiration of that call option contract. The table below sets forth, with respect to each call option contract, the number of shares of the Company's Common Stock subject to the call option and the date of expiration of the call option contract. SwissFirst Bank AG is the counterparty to each of the call option contracts. Number of Shares Contract covered by Contract Expiration Date ------------------- --------------- 50000 6/21/02 51800 6/21/02 148200 6/21/02 250000 6/21/02 250000 6/21/02 105000 9/20/02 Page 3

Number of Shares Contract covered by Contract Expiration Date ------------------- --------------- 145000 9/20/02 250000 9/20/02 203000 9/20/02 47000 9/20/02 161250 9/20/02 93824 9/20/02 500000 11/15/02 50000 11/15/02 200000 11/15/02 65000 11/15/02 44000 11/15/02 28500 11/15/02 66300 11/15/02 46200 11/15/02 250000 11/15/02 If each of the above described call option contracts is exercised in full upon expiration and the underwriters exercise the full over-allotment option described in item 4, then Holdings will no longer own any shares of the Company's Common Stock. Item 7. Material to be Filed as Exhibits 1: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/18/01 2: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/19/01 3: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/21/01 4: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/21/01 5: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/27/01 6: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/14/02 7: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/15/02 Page 4

8: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/16/02 9: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/16/02 10: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/17/02 11: Call Option Contract between Holdings and SwissFirst Bank AG dated 2/11/02 12: Call Option Contract between Holdings and SwissFirst Bank AG dated 2/12/02 13: Call Option Contract between Holdings and SwissFirst Bank AG dated 11/20/01 14: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/21/01 15: Call Option Contract between Holdings and SwissFirst Bank AG dated 11/23/01 16: Call Option Contract between Holdings and SwissFirst Bank AG dated 11/26/01 17: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/5/01 18: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/13/01 19: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/14/01 20: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/17/01 21: Call Option Contract between Holdings and SwissFirst Bank AG dated 2/11/02 22: Executive Officers and Directors of Holdings, Finance and Roche Holding. Page 5

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and accurate. Dated: February 27, 2002 ROCHE HOLDINGS, INC. By: /s/ Marcel Kohler -------------------------- Name: Marcel Kohler Title: Secretary Page 6

Index to Exhibits Exhibit 10.01: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/18/01 Exhibit 10.02: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/19/01 Exhibit 10.03: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/21/01 Exhibit 10.04: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/21/01 Exhibit 10.05: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/27/01 Exhibit 10.06: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/14/02 Exhibit 10.07: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/15/02 Exhibit 10.08: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/16/02 Exhibit 10.09: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/16/02 Exhibit 10.10: Call Option Contract between Holdings and SwissFirst Bank AG dated 1/17/02 Exhibit 10.11: Call Option Contract between Holdings and SwissFirst Bank AG dated 2/11/02 Exhibit 10.12: Call Option Contract between Holdings and SwissFirst Bank AG dated 2/12/02 Exhibit 10.13: Call Option Contract between Holdings and SwissFirst Bank AG dated 11/20/01 Exhibit 10.14: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/21/01 Exhibit 10.15: Call Option Contract between Holdings and SwissFirst Bank AG dated 11/23/01 Exhibit 10.16: Call Option Contract between Holdings and SwissFirst Bank AG dated 11/26/01 Exhibit 10.17: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/5/01 Exhibit 10.18: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/13/01 Exhibit 10.19: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/14/01 Exhibit 10.20: Call Option Contract between Holdings and SwissFirst Bank AG dated 12/17/01 Exhibit 10.21: Call Option Contract between Holdings and SwissFirst Bank AG dated 2/11/02 Exhibit 99.1: Executive Officers and Directors of Holdings, Finance and Roche Holding. Page 7

                                                                  EXHIBIT 10.01
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note

Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             50,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 18, 2001

Value Date:                      December 21, 2001

Expiration Date:                 June 21, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.06

Total Premium:                   USD 503,000

Total Underlying Value:          USD 3,750,000

Payment Instructions:
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                                Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.



                                                                   EXHIBIT 10.02
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note


Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             51,800

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 19, 2001

Value Date:                      December 24, 2001

Expiration Date:                 June 21, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.06

Total Premium:                   USD 521,108

Total Underlying Value:          USD 3,885,000

Payment Instructions:
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.







EXHIBIT 10.03 swissfirst - -------------------------------------------------------------------------------- swissfirst Bank AG OTC Contract Note Seller: Roche Holdings, Inc. Herrn M.F. Kohler Buyer: swissfirst Bank AG Herrn T. Maag Fax 01 204 81 81 Number of Contracts: 148,200 Call/Put: Call Option Style: European Underlying: Laboratory Corp of America Holdings Security Number: US50540R4092 Multiplier 1 Trade Date: December 21, 2001 Value Date: December 27, 2001 Expiration Date: June 21, 2002 Strike Price: USD 75. Price Per Option: USD 10.04 Total Premium: USD 1,487,928 Total Underlying Value: USD 11,115,000 Payment Instructions: - -------------------------------------------------------------------------------- To be transmitted by telefax to swissfirst Bank AG: Telefax Number +4441-1-204 81 81 Acknowledged by: Roche Holdings, Inc.

                                                                   EXHIBIT 10.04
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note

Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             250,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 21, 2001

Value Date:                      December 27, 2001

Expiration Date:                 June 21, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.03

Total Premium:                   USD 2,507,500

Total Underlying Value:          USD 18,750,000

Payment Instructions:
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.



                                                                   EXHIBIT 10.05
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note


Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             250,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 27, 2001

Value Date:                      January 02, 2002

Expiration Date:                 June 21, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.40

Total Premium:                   USD 2,600,000

Total Underlying Value:          USD 18,750,000

Payment Instructions:
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.





                                                                   EXHIBIT 10.06
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler
                                 Wilmington, DE 19801

Number of Contracts:             105,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      14, January, 2002

Value Date:                      17, January, 2002

Expiration Date:                 20, September, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.23

Total Premium:                   USD 1,074,150

Total Underlying Value:          USD 7,875,000

Payment Instructions:            swissfirst Bank AG. for account Nr. 3671_0
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by:         Roche Holdings, Inc.



                                                                   EXHIBIT 10.07
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note


Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler
                                 Wilmington, DE 19801

Number of Contracts:             145,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      15, January, 2002

Value Date:                      18, January, 2002

Expiration Date:                 20, September, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.09

Total Premium:                   USD 1,463,050

Total Underlying Value:          USD 10,875,000

Payment Instructions:            swissfirst Bank AG. for account Nr. 3671_0
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.




                                                                   EXHIBIT 10.08
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler
                                 Wilmington, DE 19801

Number of Contracts:             250,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      16, January, 2002

Value Date:                      22, January, 2002

Expiration Date:                 20, September, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.54

Total Premium:                   USD 2,635,000

Total Underlying Value:          USD 18,750,000

Payment Instructions:            swissfirst Bank AG. for account Nr. 3671_0
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.



                                                                   EXHIBIT 10.09
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note


Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler
                                 Wilmington, DE 19801

Number of Contracts:             203,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      16, January, 2002

Value Date:                      22, January, 2002

Expiration Date:                 20, September, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.08

Total Premium:                   USD 2,046,240

Total Underlying Value:          USD 15,225,000

Payment Instructions:            swissfirst Bank AG. for account Nr. 3671_0
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.



                                                                   EXHIBIT 10.10
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note


Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler
                                 Wilmington, DE 19801

Number of Contracts:             47,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      17, January, 2002

Value Date:                      23, January, 2002

Expiration Date:                 20, September, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 10.00

Total Premium:                   USD 470,000

Total Underlying Value:          USD 3,525,000

Payment Instructions:            swissfirst Bank AG. for account Nr. 3671_0
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by:Roche Holdings, Inc.






                                                                  EXHIBIT 10.11
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                                                              OTC Contract Note


Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler
                                 Wilmington, DE 19801

Number of Contracts:             161,250

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      11, February, 2002

Value Date:                      14, February, 2002

Expiration Date:                 20, September, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 14.48

Total Premium:                   USD 2,334,900

Total Underlying Value:          USD 12,093,750

Payment Instructions:            swissfirst Bank AG. for account Nr. 3671_0
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by:  Roche Holdings, Inc.





                                                                   EXHIBIT 10.12
swissfirst
- --------------------------------------------------------------------------------

swissfirst Bank AG

                               OTC Contract Note


Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler
                                 Wilmington, DE 19801

Number of Contracts:             93,824

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      12, February, 2002

Value Date:                      15, February, 2002

Expiration Date:                 20, September, 2002

Strike Price:                    USD 75.

Price Per Option:                USD 13.27

Total Premium:                   USD 1,245,044,48

Total Underlying Value:          USD 7,036,800

Payment Instructions:            your account 3671_0 at swissfirst Bank AG
                                 will be credited
- --------------------------------------------------------------------------------
To be transmitted by telefax to swissfirst Bank AG:
                                             Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.




                                                                  EXHIBIT 10.13
swissfirst
- --------------------------------------------------------------------------------

swissfirst Bank AG
Bellariastrasse 23
CH-8002 Zurich       OTC Contract Note                     REF:          SWFB036
                     ------------------------              ----
                     The following transaction was broked and executed
                     through swissfirst Bank AG:


Buyer:                           swissfirst Bank AG, Zurich
                                 Contact Person: Mr. M. Massarotti

Seller:                          Roche Holdings, Inc., Wilmington, USA
                                 Contact Person: Mr. Marcel F. Kohler

Number of Contracts:             500,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      November 20, 2001

Value Date:                      November 26, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 12.93

Total Premium:                   USD 6,465,000.00

Total Underlying Value:          USD 40,000,000.00

                                                                        S.E.&O.
- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG: Telefax
Number +4441-1-204 81 Acknowledged by: Roche Holdings, Inc., Wilmington,
USA

                                                                  EXHIBIT 10.14
swissfirst
- --------------------------------------------------------------------------------

swissfirst Bank AG
Bellariastrasse 23
CH-8002 Zurich         OTC Contract Note                  REF:          SWFB039
                       ------------------------           ----
                       The following transaction was broked and executed
                       through swissfirst Bank AG:


Buyer:                           swissfirst Bank AG, Zurich
                                 Contact Person: Mr. M. Massarotti

Seller:                          Roche Holdings, Inc., Wilmington, USA
                                 Contact Person: Mr. Marcel F. Kohler

Number of Contracts:             50,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      November 21, 2001

Value Date:                      November 27, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 13.44

Total Premium:                   USD 672,000.00

Total Underlying Value:          USD 400,000.00

                                                                        S.E.&O.
- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81 Acknowledged by:
Roche Holdings, Inc., Wilmington, USA

                                                                  EXHIBIT 10.15
swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                              OTC Contract Note
                              -----------------


Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             200,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      November 23, 2001

Value Date:                      November 28, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 13.1

Total Premium:                   USD 2,620,000

Total Underlying Value:          USD 16,000,000


- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.

                                                                  EXHIBIT 10.16

swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG
Bellariastrasse 23
CH-8002 Zurich                OTC Contract Note
                              ------------------------
                              The following transaction was broked and executed
                              through swissfirst Bank AG:


Seller:                          Roche Holdings, Inc., Wilmington, USA
                                 Contact Person: Mr. Marcel F. Kohler

Buyer:                           swissfirst Bank AG, Zurich
                                 Contact Person: Mr. M. Massarotti

Number of Contracts:             65,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      November 26, 2001

Value Date:                      November 29, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 13.00

Total Premium:                   USD 845,000.00

Total Underlying Value:          USD 5,200,000.00

                                                                        S.E.&O.
- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81
Acknowledged by:  Roche Holdings, Inc., Wilmington, USA

                                                                  EXHIBIT 10.17

swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                              OTC Contract Note
                              -----------------


Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             44,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 5, 2001

Value Date:                      December 10, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 11.00

Total Premium:                   USD 484,000.00

Total Underlying Value:          USD 3,520,000.00

- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81
Acknowledged by:  Roche Holdings, Inc.

                                                                  EXHIBIT 10.18

swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note
                               -----------------


Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             28,500

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 13, 2001

Value Date:                      December 18, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 10.65

Total Premium:                   USD 303,525.00

Total Underlying Value:          USD 2,280,000.00

- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81
Acknowledged by: Roche Holdings, Inc.

                                                                  EXHIBIT 10.19

swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note
                               -----------------

Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             66,300

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 14, 2001

Value Date:                      December 19, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 10.62

Total Premium:                   USD 704,106

Total Underlying Value:          USD 5,304,000

- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81
Acknowledged by:  Roche Holdings, Inc.

                                                                  EXHIBIT 10.20

swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note
                               -----------------

Seller:                          Roche Holdings, Inc.
                                 Herrn M.F. Kohler

Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Number of Contracts:             46,200

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      December 17, 2001

Value Date:                      December 20, 2001

Expiration Date:                 November 15, 2002

Strike Price:                    USD 80.00

Price Per Option:                USD 10.59

Total Premium:                   USD 489,528

Total Underlying Value:          USD 3,696,000

- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81
Acknowledged by:  Roche Holdings, Inc.

                                                                   EXHIBIT 10.21

swissfirst
- --------------------------------------------------------------------------------
swissfirst Bank AG

                               OTC Contract Note
                               -----------------


Buyer:                           swissfirst Bank AG
                                 Herrn T. Maag
                                 Fax 01 204 81 81

Seller:                          Roche Holdings, Inc.
                                 Mr. Marcel F. Kohler

Number of Contracts:             250,000

Call/Put:                        Call

Option Style:                    European

Underlying:                      Laboratory Corp of America Holdings

Security Number:                 US50540R4092

Multiplier                       1

Trade Date:                      11, February 2002

Value Date:                      14, February 2002

Expiration Date:                 15, November 2002

Strike Price:                    USD 80

Price Per Option:                USD 12.92

Total Premium:                   USD 3,320,000

Total Underlying Value:          USD 20,000,000

Payment Instructions             swissfirst Bank AG. for account Nr. 3671_0

- --------------------------------------------------------------------------------

To be transmitted by telefax to swissfirst Bank AG:
Telefax Number +4441-1-204 81 81
Acknowledged by:  Roche Holdings, Inc.

                                                                   EXHIBIT 99.1
                                                                     SCHEDULE A



                      Executive Officers and Directors (*)
                                       of
                              Roche Holdings, Inc.


     The names of the Directors and the names and titles of the Executive
Officers of Roche Holdings, Inc. and their business addresses and principal
occupations are set forth below. If no address is given, the Director's or
Executive Officer's business address is that of Roche Holding Ltd which is
Grenzacherstrasse 124, 4002 Basel, Switzerland. Unless otherwise indicated,
each occupation set forth opposite an individual's name refers to Roche Holding
Ltd and each individual is a Swiss citizen.



Name, Business Address                   Present Principal Occupation

* Dr. h.c. Fritz Gerber..................Chairman of the Board and President
* Dr.  Franz B. Humer....................Vice President
* Dr. Erich Hunziker.....................Vice President- Finance and Treasurer


                                                                     SCHEDULE B


                      Executive Officers and Directors (*)
                                       of
                               Roche Finance Ltd


     The names of the Directors and the names and titles of the Executive
Officers of Roche Finance Ltd and their business addresses and principal
occupations are set forth below. If no address is given, the Director's or
Executive Officer's business address is that of Roche Holding Ltd, which is
Grenzacherstrasse 124, 4002 Basel, Switzerland. Unless otherwise indicated,
each occupation set forth opposite an individual's name refers to Roche Holding
Ltd and each individual is a Swiss citizen.



Name, Business Address                             Present Principal Occupation

* Dr. Franz B. Humer...............................President
* Dr. Erich Hunziker...............................Director
* Dr. Gottlieb Keller..............................Director


SCHEDULE C Executive Officers and Directors of Roche Holding Ltd The names of the Directors and the names and titles of the Executive Officers of Roche Holding Ltd and their business addresses and principal occupations are set forth below. If no address is given, the Director's or Executive Officer's business address is that of Roche Holding Ltd, which is Grenzacherstrasse 124, 4002 Basel, Switzerland. Unless otherwise indicated, each occupation set forth opposite an individual's name refers to Roche Holding Ltd and each individual is a Swiss citizen, except that Mr. Brabeck-Letmathe is an Austrian citizen, Mr. von Prondzynski is a German citizen, Professor Bell is a Canadian citizen and Mr. Burns and Professor Knowles are citizens of the United Kingdom. Dr. Gottlieb A. Keller is the Secretary to the Board of Directors. Mr. Pierre Jaccoud is the Secretary to the Executive Committee. Board of Directors Dr. Franz B. Humer Chairman Dr. Andres F. Leuenberger Vice-Chairman Dr. Rolf Hanggi Vice-Chairman Mr. Peter Brabeck-Letmathe Chief Executive Officer of Nestle Nestle SA Avenue Nestle, CH-1800 Verey Mr. Andre Hoffman Businessman Massellaz S.A. Place du Casino 4 1110 Morges Dr. h.c. Fritz Gerber Businessman Dr. Henri B. Meier Businessman Dr. Andreas Oeri Surgeon Praxisgemeinschaft Clarahof Clarahofweg 19a CH-4005 Basel Professor John Bell University Professor Nuffield Professor of Clinical Medicine University of Oxford Level 7, John Radcliffe Hospital Headington, Oxford OX 3 9DU United Kingdom Mr.Walter Frey Chairman of the Board of Directors Prasident des Verwaltungsrates of Emil Frey A.G. Emil Frey AG Badenerstrasse 600 8048 Zurich

Executive Committee Dr. Franz B. Humer Chief Executive Officer Dr. Erich Hunziker Chief Financial Officer Mr. William M. Burns Pharmaceuticals Division Mr. Heino von Prondzynski Diagnostics Division Dr. Markus Altwegg Vitamins and Fine Chemicals Division Mr. Richard Laube Pharma Consumer Health Professor Jonathan Knowles Global Pharmaceutical Research Dr. Daniel Villiger Corporate Services